Mechanism of the Enantioselective Oxidation of Racemic Secondary Alcohols Catalyzed by Chiral Mn(III)−Salen Complexes
نویسندگان
چکیده
منابع مشابه
Enantioselective oxidation of racemic secondary alcohols catalyzed by chiral Mn(III)-salen complexes with N-bromosuccinimide as a powerful oxidant.
We demonstrate an efficient enantioselective oxidation of secondary alcohols catalyzed by Mn(III)-salen complex using N-bromosuccinimide (NBS) as the oxidant. The new protocol is very efficient for the oxidative kinetic resolution of a variety of secondary alcohols, including ortho-substituted benzylic alcohols.
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An efficient, economic and environmentally friendly enantioselective oxidation of racemic benzoins (alpha-hydroxy ketones) catalyzed by a chiral iron complex has been developed using molecular oxygen as a terminal oxidant with good selectivity and excellent enantiomeric excess.
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Enantiomerically pure secondary alcohols are essential compounds in organic synthesis and are used as chiral auxiliaries and synthetic intermediates in the pharmaceutical, agrochemical, and fine chemical industries. One of the attractive and practical approaches to achieving optically pure secondary alcohols is oxidative kinetic resolution of racemic secondary alcohols using chiral Mn(III) sale...
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Enantioenriched alcohols are ubiquitous in the structures and syntheses of natural products and pharmaceuticals. Catalytic, asymmetric alcohol oxidation can be a useful method to access these molecules.[1] Previously, we reported the development of an aerobic kinetic resolution of alcohols by catalytic [Pd(nbd)Cl2] (1, nbd = norbornadiene) and the naturally occurring alkaloid (−)-sparteine (sp,...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2010
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja103103d